In Silico Molecular Docking, Synthesis and Preliminary Evaluation of Antibacterial Activity of Levofloxacin Carboxamides with Certain Amino Acids

Levofloxacin carboxamides with certain amino acids were prepared through an amide linkage to the acid (glycine, histidine, or serine). These subjected in silico molecular docking evaluation on
 
 DNA gyrase predict their antibacterial activity using GOLD suite. The binding affinities very significant and encouraged synthesis of suggested for intensive evaluation. also Swiss ADME software parameters. high yield, chemical structures confirmed by spectral analysis, such as 1H-NMR, 13C-NMR FT-IR spectroscopy. Antibacterial activities evaluated new against two G-ve (Klebsiella P. aeruginosa) one G+ve (Streptococcus pneumonia) bacteria. When compared levofloxacin, all synthesized 1-3 demonstrated good three types showed S. pneumoniae lower Klebsiella.